Glutamine is a critical nutrient in cancer; however, its contribution to purine metabolism in
prostate cancer has not previously been determined. Guanosine monophosphate
synthetase (GMPS) acts in the de novo purine biosynthesis pathway, utilizing a glutamine
amide to synthesize the guanine nucleotide. This study demonstrates that GMPS mRNA
expression correlates with Gleason score in prostate cancer samples, while high GMPS
expression was associated with decreased rates of overall and disease/progression‐free …

Cancer cells increase their uptake of nutrients and metabolize them to provide the
necessary building blocks for new cancer cells. Glutamine is a critical nutrient in cancer,
however its contribution to purine metabolism in prostate cancer has not previously been
determined. Guanosine monophosphate synthetase (GMPS) acts in the de novo purine
biosynthesis pathway, utilizing a glutamine amide to synthesize the guanine nucleotide and
replenish the purine pool in proliferative cancer cells. This study demonstrates that GMPS …