Inhibitory effect of PCSK9 on Abca1 protein expression and cholesterol efflux in macrophages
Background and aims Proprotein convertase subtilisin/kexin type 9 (PCSK9) may have extra-
hepatic effects on cholesterol homeostasis of vascular macrophages. In this study, we aimed
to investigate PCSK9 role on the anti-atherogenic process of ATP binding cassette
transporter A1 (Abca1)-mediated cholesterol efflux. Methods Abca1-mediated cholesterol
efflux was evaluated by a radioisotopic technique in mouse peritoneal macrophages (MPM)
from wild-type (WT) or LDL receptor knock-out (Ldlr−/−) mice exposed to human …
hepatic effects on cholesterol homeostasis of vascular macrophages. In this study, we aimed
to investigate PCSK9 role on the anti-atherogenic process of ATP binding cassette
transporter A1 (Abca1)-mediated cholesterol efflux. Methods Abca1-mediated cholesterol
efflux was evaluated by a radioisotopic technique in mouse peritoneal macrophages (MPM)
from wild-type (WT) or LDL receptor knock-out (Ldlr−/−) mice exposed to human …
以上显示的是最相近的搜索结果。 查看全部搜索结果