Inhibitory effect of Ruta graveolens L. on oxidative damage, inflammation and aortic pathology in hypercholesteromic rats

M Ratheesh, GL Shyni, G Sindhu, A Helen - Experimental and Toxicologic …, 2011 - Elsevier
The purpose of the study was to investigate the efficacy of methanolic extract of Ruta
graveolens L. in reducing oxidative damage, inflammation and aortic pathology in
hypercholesteremic rats. For the study rats were divided into three groups–control group,
hypercholesteremic group and treatment group (20mg MER/kg/d orally)–and were fed for 90
days. Serum total cholesterol, LDL-C, total WBC count, CRP level, TBARS, atherogenic
index, activities of COX, 15 LOX in monocyte and serum myeloperoxidase were increased in …
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