Curcumin, a dietary spice from turmeric, is known to be anti-inflammatory, anticarcinogenic,
and antithrombotic. Here, we studied the mechanism of the antiplatelet action of curcumin.
We show that curcumin inhibited platelet aggregation mediated by the platelet agonists
epinephrine (200 μM), ADP (4 μM), platelet-activating factor (PAF; 800 nM), collagen (20
μg/mL), and arachidonic acid (AA: 0.75 mM). Curcumin preferentially inhibited PAF-and AA-
induced aggregation (ic50; 25–20 μM), whereas much higher concentrations of curcumin …

Inhibitory effect of curcumin, a food spice from turmeric, on platelet-activating factor- and
arachidonic acid-mediated platelet aggregation through inhibition of thromboxane formation
and Ca^<2+> signaling | CiNii Research … Inhibitory effect of curcumin, a food spice from
turmeric, on platelet-activating factor- and arachidonic acid-mediated platelet aggregation
through inhibition of thromboxane formation and Ca^<2+> signaling …