The inhibition of inflammation-associated angiogenesis ameliorates inflammatory diseases
by reducing the recruitment of tissue-infiltrating leukocytes. However, it is not known if
angiogenesis has an active role during the initiation of inflammation or if it is merely a
secondary effect occurring in response to stimuli by tissue-infiltrating leukocytes. Here, we
show that angiogenesis precedes leukocyte infiltration in experimental models of
inflammatory bowel disease and acute graft-versus-host disease (GVHD). We found that …

Angiogenesis and inflammation are two closely related processes and inhibition of
angiogenesis can ameliorate inflammatory diseases by reducing the recruitment of tissue
infiltrating leukocytes. However, there is limited evidence on initial mechanisms of both
processes and it is unknown if angiogenesis contributes to initiation of inflammation or is a
mere consequence of inflammation. Recent research showed that graft-versus-host disease
(GVHD) is associated to angiogenesis making the endothelium a potential new therapeutic …