[HTML][HTML] Inorganic polyphosphate promotes cyclin D1 synthesis through activation of mTOR/Wnt/β‐catenin signaling in endothelial cells
SM Hassanian, A Ardeshirylajimi, P Dinarvand… - Journal of Thrombosis …, 2016 - Elsevier
Essentials• Polyphosphate (polyP) activates mTOR but its role in Wnt/β‐catenin signaling is
not known.• PolyP‐mediated cyclin D1 expression (β‐catenin target gene) was monitored in
endothelial cells.• PolyP and boiled platelet‐releasates induced the expression of cyclin D1
by similar mechanisms.• PolyP establishes crosstalk between mTOR and Wnt/β‐catenin
signaling in endothelial cells. Acknowledgements We thank SA Smith from the University of
Illinois, Urbana, for preparing the platelet releasates and A. Rezaie for reading the …
not known.• PolyP‐mediated cyclin D1 expression (β‐catenin target gene) was monitored in
endothelial cells.• PolyP and boiled platelet‐releasates induced the expression of cyclin D1
by similar mechanisms.• PolyP establishes crosstalk between mTOR and Wnt/β‐catenin
signaling in endothelial cells. Acknowledgements We thank SA Smith from the University of
Illinois, Urbana, for preparing the platelet releasates and A. Rezaie for reading the …
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