Inside the biochemical pathways of thymidylate synthase perturbed by anticancer drugs: Novel strategies to overcome cancer chemoresistance
Our current understanding of the mechanisms of action of antitumor agents and the precise
mechanisms underlying drug resistance is that these two processes are directly linked.
Moreover, it is often possible to delineate chemoresistance mechanisms based on the
specific mechanism of action of a given anticancer drug. A more holistic approach to the
chemoresistance problem suggests that entire metabolic pathways, rather than single
enzyme targets may better explain and educate us about the complexity of the cellular …
mechanisms underlying drug resistance is that these two processes are directly linked.
Moreover, it is often possible to delineate chemoresistance mechanisms based on the
specific mechanism of action of a given anticancer drug. A more holistic approach to the
chemoresistance problem suggests that entire metabolic pathways, rather than single
enzyme targets may better explain and educate us about the complexity of the cellular …
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