[PDF][PDF] Insignificant anticonvulsant activity of Padina tetrastromatica (Brown macroalgae) in mice
SR Yende - Journal of Pharmaceutical Negative Results, 2016 - pnrjournal.com
SR Yende
Journal of Pharmaceutical Negative Results, 2016•pnrjournal.comIntroduction: Marine macroalgae or seaweeds are found in the coastal region havecreated a
promising significance in the biomedical area, mainly because of their contentsof bioactive
substances. The objective of the present study was to investigate theanticonvulsant activity
of chloroform and ethanol extracts of Padina tetrastromatica (PT), a marine macroalgae
(brown algae) in mice. Materials and Methods: The anticonvulsantactivity of chloroform and
ethanol extracts of PT was studied at 400 and 600 mg/kg, against maximal electroshock …
promising significance in the biomedical area, mainly because of their contentsof bioactive
substances. The objective of the present study was to investigate theanticonvulsant activity
of chloroform and ethanol extracts of Padina tetrastromatica (PT), a marine macroalgae
(brown algae) in mice. Materials and Methods: The anticonvulsantactivity of chloroform and
ethanol extracts of PT was studied at 400 and 600 mg/kg, against maximal electroshock …
Introduction
Marine macroalgae or seaweeds are found in the coastal region havecreated a promising significance in the biomedical area, mainly because of their contentsof bioactive substances. The objective of the present study was to investigate theanticonvulsant activity of chloroform and ethanol extracts of Padina tetrastromatica (PT),a marine macroalgae (brown algae) in mice.
Materials and Methods
The anticonvulsantactivity of chloroform and ethanol extracts of PT was studied at 400 and 600 mg/kg,against maximal electroshock (MES) and pentylenetetrazole (PTZ) induced convulsionin mice. The duration of tonic hind limb extension (THLE), latency to onset of clonicconvulsions and percent protection was noted in MES and PTZ tests, respectively.Phenytoin (25 mg/kg) and phenobarbitone (20 mg/kg) served as reference standards.
Results
The chloroform extract of PT at 600 mg/kg significantly decreased theduration of THLE, while ethanol extract did not alter the duration of THLE in MESmodel. Further, chloroform and ethanol extracts of PT was found to be ineffective as ananticonvulsant when assessed by PTZ‑induced convulsive model, as compared to theirrespective vehicle‑treated groups.
Conclusion
From the results of the present study itcan be concluded that the chloroform extract of PT at 600 mg/kg showed significantanticonvulsant activity, while other extracts lack anticonvulsant activity in MES andPTZ model. However, further studies are required using different animal models tosupport these findings.
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