Insulin-Increased L-Arginine Transport Requires A2A Adenosine Receptors Activation in Human Umbilical Vein Endothelium
Adenosine causes vasodilation of human placenta vasculature by increasing the transport of
arginine via cationic amino acid transporters 1 (hCAT-1). This process involves the
activation of A2A adenosine receptors (A2AAR) in human umbilical vein endothelial cells
(HUVECs). Insulin increases hCAT-1 activity and expression in HUVECs, and A2AAR
stimulation increases insulin sensitivity in subjects with insulin resistance. However, whether
A2AAR plays a role in insulin-mediated increase in L-arginine transport in HUVECs is …
arginine via cationic amino acid transporters 1 (hCAT-1). This process involves the
activation of A2A adenosine receptors (A2AAR) in human umbilical vein endothelial cells
(HUVECs). Insulin increases hCAT-1 activity and expression in HUVECs, and A2AAR
stimulation increases insulin sensitivity in subjects with insulin resistance. However, whether
A2AAR plays a role in insulin-mediated increase in L-arginine transport in HUVECs is …
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