Integrin-mediated Activation of Focal Adhesion Kinase Is Independent of Focal Adhesion Formation or Integrin Activation: STUDIES WITH ACTIVATED AND …
S Lyman, A Gilmore, K Burridge, S Gidwitz… - Journal of Biological …, 1997 - ASBMB
Integrin α IIb β 3 functions as the fibrinogen receptor on platelets and mediates platelet
aggregation and clot retraction. Among the events that occur during either" inside-out" or"
outside-in" signaling through α IIb β 3 is the phosphorylation of focal adhesion kinase
(pp125 FAK) and the association of pp125 FAK with cytoskeletal components. To examine
the role of pp125 FAK in these integrin-mediated events, pp125 FAK phosphorylation and
association with the cytoskeleton was determined in cells expressing two mutant forms of α …
aggregation and clot retraction. Among the events that occur during either" inside-out" or"
outside-in" signaling through α IIb β 3 is the phosphorylation of focal adhesion kinase
(pp125 FAK) and the association of pp125 FAK with cytoskeletal components. To examine
the role of pp125 FAK in these integrin-mediated events, pp125 FAK phosphorylation and
association with the cytoskeleton was determined in cells expressing two mutant forms of α …
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