[PDF][PDF] Interaction of a-mannosidase from aspergillus fischeri with glycosidase inhibitors, metal ions and group specific reagents
As an initial step towards using omannosidase as a target against anticancer drugs,
inhibition studies of a model enzyme, class II ozmannosida se from Aspergillus fischeri in
presence of polyhydroxy piperidine de rived glycosida se inhibitors, metal ions and amino
acid specific reagents were carried out to reveal the sensitivity of the enzyme. Three of the
derivatives (Compound 20, 32 and 39) showed competitive inhibition (K,= 45, 48 and 235
uM) and the binding of the inhibitors to the enzyme was entropically driven. Among the metal …
inhibition studies of a model enzyme, class II ozmannosida se from Aspergillus fischeri in
presence of polyhydroxy piperidine de rived glycosida se inhibitors, metal ions and amino
acid specific reagents were carried out to reveal the sensitivity of the enzyme. Three of the
derivatives (Compound 20, 32 and 39) showed competitive inhibition (K,= 45, 48 and 235
uM) and the binding of the inhibitors to the enzyme was entropically driven. Among the metal …
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