In this work we address the application of pseudopotentials directly on high-order lattice Boltzmann models. We derive a general expression for the pressure tensor on high-order lattices considering all nonideal interactions, including intra- and intermolecular interactions, following the discrete lattice theory introduced by X. Shan [Phys. Rev. E 77, 066702 (2008)PLEEE81539-375510.1103/PhysRevE.77.066702]. From the derived expression, a generalized continuum approximation, truncated at fourth-order isotropy, is obtained that is readily applicable to high-order lattices. With this, we demonstrate that high-order lattice models with pseudopotentials can satisfy thermodynamic consistency. The derived generalized expression and continuum approximation are validated for the case of a flat interface and compared against the standard definition available from the literature. The generalized expression is also shown to accurately reproduce the Laplace experiment for a variety of high-order lattice structures. This work sets the preliminary steps towards the application of high-order lattice models for simulating nonideal fluid mixtures.