Interactions between genes and the environment. Epigenetics in allergy

M Isidoro-García, I Davila-Gonzalez… - Allergologia et …, 2007 - Elsevier
Epigenetics is defined as those inheritable changes occurring in gene expression, without
actual modification in the genic DNA sequence. Epigenetic factors are chemically stable,
potentially reversible, and can be modulated or induced by environmental factors. In the
case of allergic disease, epigenetics could explain not only the discordances observed
between monozygous twins but also phenomena such as incomplete penetrance, variable
expression, gender and progenitor effects, and sporadic cases. In this sense, the hypothesis …
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