Scaling-up optical quantum technologies requires a combination of highly efficient multi-photon sources and integrated waveguide components. Here, we interface these scalable platforms, demonstrating high-rate three-photon interference with a quantum dot based multi-photon source and a reconfigurable photonic chip on glass. We actively demultiplex the temporal train of single photons obtained from a quantum emitter to generate a 3.8×10^3 s^−1three-photon source, which is then sent to the input of a tunable tritter circuit, demonstrating the on-chip quantum interference of three indistinguishable single photons. We show via pseudo number-resolving photon detection characterizing the output distribution that this first combination of scalable sources and reconfigurable photonic circuits compares favorably in performance with respect to previous implementations. Our detailed loss-budget shows that merging solid-state multi-photon sources and reconfigurable photonic chips could allow 10-photon experiments on chip at ∼40 s^−1 rate in a foreseeable future.