Interferon-signature in idiopathic inflammatory myopathies
L Gallay, G Mouchiroud, B Chazaud - Current Opinion in …, 2019 - journals.lww.com
L Gallay, G Mouchiroud, B Chazaud
Current Opinion in Rheumatology, 2019•journals.lww.comIIM pathogenesis remains partially understood. IFN-signature represents one of the main
recent advances in the field. IFN-signature was identified thanks to transcriptomic analyses
of tissues or cells from IIM patients (muscle, skin, blood cells, muscle cells) and should allow
to establish new diagnosis and better monitoring of IIM patients. It also provides a tool for
investigation of IIM pathogenesis. Nevertheless, IFN-signature still requires accurate
definition in order to standardize its use, notably in the clinical practice.
recent advances in the field. IFN-signature was identified thanks to transcriptomic analyses
of tissues or cells from IIM patients (muscle, skin, blood cells, muscle cells) and should allow
to establish new diagnosis and better monitoring of IIM patients. It also provides a tool for
investigation of IIM pathogenesis. Nevertheless, IFN-signature still requires accurate
definition in order to standardize its use, notably in the clinical practice.
Summary
IIM pathogenesis remains partially understood. IFN-signature represents one of the main recent advances in the field. IFN-signature was identified thanks to transcriptomic analyses of tissues or cells from IIM patients (muscle, skin, blood cells, muscle cells) and should allow to establish new diagnosis and better monitoring of IIM patients. It also provides a tool for investigation of IIM pathogenesis. Nevertheless, IFN-signature still requires accurate definition in order to standardize its use, notably in the clinical practice.
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