Interferon-stimulated and metallothionein-expressing macrophages are associated with acute and chronic allograft dysfunction after lung transplantation
Background Lung transplant recipients experience episodes of immune-mediated acute
lung allograft dysfunction (ALAD). ALAD episodes are a risk factor for chronic lung allograft
dysfunction (CLAD), the major cause of death after lung transplantation. Our objective was to
determine key cellular elements in dysfunctional lung allografts, with a focus on
macrophages. Methods We have applied single-cell RNA sequencing (scRNAseq) to
bronchoalveolar lavage cells from stable and ALAD patients and to cells from explanted …
lung allograft dysfunction (ALAD). ALAD episodes are a risk factor for chronic lung allograft
dysfunction (CLAD), the major cause of death after lung transplantation. Our objective was to
determine key cellular elements in dysfunctional lung allografts, with a focus on
macrophages. Methods We have applied single-cell RNA sequencing (scRNAseq) to
bronchoalveolar lavage cells from stable and ALAD patients and to cells from explanted …
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