… that these associations have included enhanced hypoxia inducible factor (HIF)-1α and
vascular … in the tumor and altered immune functions via intermittent hypoxia (IH). Here, we …

… the left coronary artery is occluded, cardiac tissue that is normally perfused by this artery
rapidly becomes hypoxic; and 3) severe blood loss results in systemic hypoxia due to reduced …

… and stromal cell-derived factor-1α and increasing leukocyte … associated with disease
progression of vascular malformations. In a recent study, the expression of HIF-1α was increased …

… that simulated the timing and magnitude of arterial oxygen desaturation changes seen in
OSA patients (58). During each period of IH, the Fi O 2 was reduced from 20.9 to 4.9 ± 0.1% …

… chronic intermittent hypoxia that occurs as a result of obstructive sleep apnea and causes
cardiovascular … Despite the fact that intermittent hypoxia involves short (15–30 s) episodes of …

… While hypoxia is a proliferative stimulus for pulmonary artery adventitial fibroblasts, 27 our
… of fibroblast activity in the setting of intermittent hypoxia. Hypoxia in the rat has also been …

… Furthermore, Kaczmarek et al. demonstrated that IH-induced … distinct vascular beds [46].
On the other hand, our study of RASMCs found that sustained hypoxia (1% O 2 ) induced a large …

… and vascular diseases. We also discuss novel oxygen-independent regulatory proteins …
Hypoxia-inducible factor-1α was originally identified as a protein whose binding to the HRE in …

… Poor cardiovascular outcomes may be related to the high prevalence of atherosclerosis in …
models of intermittent hypoxia (IH). We have previously demonstrated in mice that IH induces …

… of intermittent hypoxia on serum lipid level, hepatic low-density lipoprotein receptor-related
protein (LRP)1, and hepatic hypoxia-inducible … both cause significant arterial hypoxemia and …