Interspecies variations of corticosteroid-binding globulin parameters
V Gayrard, M Alvinerie, PL Toutain - Domestic Animal Endocrinology, 1996 - Elsevier
In mammalian plasma, cortisol binds to a specific α1-glycoprotein: corticosteroid-binding
globulin (CBG). In this study, we measured the protein binding of cortisol by equilibrium
dialysis in seven species in which plasma cortisol concentrations varied from 0.02 to 0.05
(ewe, dog, cow) to 0.1 to 0.6 (horse, human, cynomolgus monkey) to reach 1.6 μM (squirrel
monkey). No binding of cortisol to CBG was discernible in plasma from squirrel monkey. In
all other species examined, we showed that the CBG maximal capacity (Bmax) was 3 (1.7 to …
globulin (CBG). In this study, we measured the protein binding of cortisol by equilibrium
dialysis in seven species in which plasma cortisol concentrations varied from 0.02 to 0.05
(ewe, dog, cow) to 0.1 to 0.6 (horse, human, cynomolgus monkey) to reach 1.6 μM (squirrel
monkey). No binding of cortisol to CBG was discernible in plasma from squirrel monkey. In
all other species examined, we showed that the CBG maximal capacity (Bmax) was 3 (1.7 to …
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