[HTML][HTML] Interstitial microRNA miR-214 attenuates inflammation and polycystic kidney disease progression
Renal cysts are the defining feature of autosomal dominant polycystic kidney disease
(ADPKD); however, the substantial interstitial inflammation is an often-overlooked aspect of
this disorder. Recent studies suggest that immune cells in the cyst microenvironment affect
ADPKD progression. Here we report that microRNAs (miRNAs) are new molecular signals in
this crosstalk. We found that miR-214 and its host long noncoding RNA Dnm3os are
upregulated in orthologous ADPKD mouse models and cystic kidneys from humans with …
(ADPKD); however, the substantial interstitial inflammation is an often-overlooked aspect of
this disorder. Recent studies suggest that immune cells in the cyst microenvironment affect
ADPKD progression. Here we report that microRNAs (miRNAs) are new molecular signals in
this crosstalk. We found that miR-214 and its host long noncoding RNA Dnm3os are
upregulated in orthologous ADPKD mouse models and cystic kidneys from humans with …
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