Intimate Molecular Interactions of P. falciparum Merozoite Proteins Involved in Invasion of Red Blood Cells and Their Implications for Vaccine Design
LE Rodriguez, H Curtidor, M Urquiza… - Chemical …, 2008 - ACS Publications
Chemical Reviews, 2008•ACS Publications
… A completely effective vaccine has not yet been developed against this disease, mainly
due to the incomplete knowledge of the intimate molecular interactions between parasite
proteins and their specific host cell membrane receptor(s) during invasion. There is also a
lack of complete information regarding the structural and immunological properties of
antigens able to activate the very complex mechanisms of protection-inducing immunity. A
thorough analysis of the intimate molecular interactions of the molecules involved in the …
due to the incomplete knowledge of the intimate molecular interactions between parasite
proteins and their specific host cell membrane receptor(s) during invasion. There is also a
lack of complete information regarding the structural and immunological properties of
antigens able to activate the very complex mechanisms of protection-inducing immunity. A
thorough analysis of the intimate molecular interactions of the molecules involved in the …
Malaria continues to be one of the main public health problems for mankind; it is the transmissible disease with the greatest morbidity and mortality around the world. It kills
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