Intracellular target delivery of cell-penetrating peptide-conjugated dodecaborate for boron neutron capture therapy (BNCT)
I Nakase, M Katayama, Y Hattori, M Ishimura… - Chemical …, 2019 - pubs.rsc.org
I Nakase, M Katayama, Y Hattori, M Ishimura, S Inaura, D Fujiwara, T Takatani-Nakase…
Chemical Communications, 2019•pubs.rsc.orgIn this study, we designed and synthesized organelle-targeted cell-penetrating peptide
(CPP)-conjugated boron compounds to increase their cellular uptake and to control the
intracellular locations for the induction of sophisticated anticancer biological activity in boron
neutron capture therapy (BNCT), leading to anticancer effects with ATP reduction and
apoptosis when irradiated with neutrons in an in vitro BNCT assay.
(CPP)-conjugated boron compounds to increase their cellular uptake and to control the
intracellular locations for the induction of sophisticated anticancer biological activity in boron
neutron capture therapy (BNCT), leading to anticancer effects with ATP reduction and
apoptosis when irradiated with neutrons in an in vitro BNCT assay.
In this study, we designed and synthesized organelle-targeted cell-penetrating peptide (CPP)-conjugated boron compounds to increase their cellular uptake and to control the intracellular locations for the induction of sophisticated anticancer biological activity in boron neutron capture therapy (BNCT), leading to anticancer effects with ATP reduction and apoptosis when irradiated with neutrons in an in vitro BNCT assay.
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