Intrinsic disorder in BAP1 and its association with uveal melanoma
Background: Specific subvariants of uveal melanoma (UM) are associated with increased
rates of metastasis compared to other subvariants. BRCA1 (BReast CAncer gene 1)-
associated protein-1 (BAP1) is encoded by a gene that has been linked to aggressive
behavior in UM. Methods: We evaluated BAP1 for the presence of intrinsically disordered
protein regions (IDPRs) and its protein–protein interactions (PPI). We evaluated specific
sequence-based features of the BAP1 protein using a set of bioinformatic databases …
rates of metastasis compared to other subvariants. BRCA1 (BReast CAncer gene 1)-
associated protein-1 (BAP1) is encoded by a gene that has been linked to aggressive
behavior in UM. Methods: We evaluated BAP1 for the presence of intrinsically disordered
protein regions (IDPRs) and its protein–protein interactions (PPI). We evaluated specific
sequence-based features of the BAP1 protein using a set of bioinformatic databases …
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