Investigating regulatory signatures of human autophagy related gene 5 (ATG5) through functional in silico analysis
Autophagy is an essential, homeostatic process which removes damaged cellular proteins
and organelles for cellular renewal. ATG5, a part of E3 ubiquitin ligase-like complex (Atg12-
Atg5/Atg16L1), is a key regulator involved in autophagosome formation-a crucial phase of
autophagy. In this study, we used different in silico methods for comprehensive analysis of
ATG5 to investigate its less explored regulatory activity. We have predicted various physico-
chemical parameters and two possible transmembrane models that helped in exposing its …
and organelles for cellular renewal. ATG5, a part of E3 ubiquitin ligase-like complex (Atg12-
Atg5/Atg16L1), is a key regulator involved in autophagosome formation-a crucial phase of
autophagy. In this study, we used different in silico methods for comprehensive analysis of
ATG5 to investigate its less explored regulatory activity. We have predicted various physico-
chemical parameters and two possible transmembrane models that helped in exposing its …
[引用][C] Investigating regulatory signatures of human autophagy related gene 5 (ATG5) through functional in silico analysis. Meta Gene 2016; 9: 237-48
A Vij, R Randhawa, J Parkash, H Changotra