There are several factors that influence the potential for crash occurrence. These factors can be summarized as road environment, vehicle defects, driver and pedestrian behavior. Often, the influence of these factors on the likelihood of a potential crash or post-crash injury severity have been addressed independently without considering their synergy effect. This study aims at exploring co-variation of driver and pedestrian actions prior to a crash and link their interactive effect on injury severity level. Vehicle condition prior to crash was not included in the scope of this study and the focus was only on crashes involving one vehicle and one pedestrian. This scenario covered 90 percent of all pedestrian crashes that were available. Tetrachoric correlation was used to measure the association between involved parties conditions and their corresponding hazardous actions prior to crash. A generalized ordered logit model was used to test the significance of interactive driver-pedestrian pre-crash hazardous action scenarios to crash severity levels. The results showed that interaction of speeding by driver with a pedestrian who was not at fault and interaction between failures to yield by a pedestrian with driver not at fault had a significant effect on fatal and incapacitating injury. The first scenario was significantly correlated with the icy and snowy road environment while the second scenario had a significant association with pedestrian who had been drinking before the crash.