Tensile tests were performed on high-purity W and Mo polycrystals at room temperature for a range of axial strain-rates 2.1 × 10⁻⁴–2.1 × 10⁻² s⁻¹. The critical resolved shear stress (CRSS) data was analyzed by using the analytical formulation for the strain-rate dependence of the CRSS derived in the kink-pair nucleation (KPN) model of flow stress in crystals with high intrinsic lattice friction. On evaluation of various microscopic slip-parameters of the model, the active slip-system in both W and Mo polycrystals was identified as {110}<111>. This is in good agreement with that deduced from the published data on the temperature dependence of the CRSS of these crystals as well as from the observed slip-lines on the deformed crystals reported in the literature. Moreover, the available data on the temperature dependence of the CRSS of Mo, Nb, Fe, V, and K crystals were also analyzed within the framework of the KPN model of flow stress. Peierls mechanism was found to be responsible for the CRSS of these metals; the active slip-systems in refractory metals Mo, Nb, Fe, and V were {110}<111> and {211}<111> whereas that in alkali metal K was {321}<111>.