Involvement of a eukaryotic-like ubiquitin-related modifier in the proteasome pathway of the archaeon Sulfolobus acidocaldarius
In eukaryotes, the covalent attachment of ubiquitin chains directs substrates to the
proteasome for degradation. Recently, ubiquitin-like modifications have also been described
in the archaeal domain of life. It has subsequently been hypothesized that ubiquitin-like
proteasomal degradation might also operate in these microbes, since all archaeal species
utilize homologues of the eukaryotic proteasome. Here we perform a structural and
biochemical analysis of a ubiquitin-like modification pathway in the archaeon Sulfolobus …
proteasome for degradation. Recently, ubiquitin-like modifications have also been described
in the archaeal domain of life. It has subsequently been hypothesized that ubiquitin-like
proteasomal degradation might also operate in these microbes, since all archaeal species
utilize homologues of the eukaryotic proteasome. Here we perform a structural and
biochemical analysis of a ubiquitin-like modification pathway in the archaeon Sulfolobus …
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