Involvement of the 90 kDa heat shock protein during adaptation of Paracoccidioides brasiliensis to different environmental conditions
HSP90 is a molecular chaperone that participates in folding, stabilization, activation, and
assembly of several proteins, all of which are key regulators in cell signaling. In dimorphic
pathogenic fungi such as Paracoccidioides brasiliensis, the adaptation to a higher
temperature, acid pH and oxidative stress, is an essential event for fungal survival and also
for the establishing of the infectious process. To further understand the role of this protein,
we used antisense RNA technology to generate a P. brasiliensis isolate with reduced …
assembly of several proteins, all of which are key regulators in cell signaling. In dimorphic
pathogenic fungi such as Paracoccidioides brasiliensis, the adaptation to a higher
temperature, acid pH and oxidative stress, is an essential event for fungal survival and also
for the establishing of the infectious process. To further understand the role of this protein,
we used antisense RNA technology to generate a P. brasiliensis isolate with reduced …
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