Iron and Alzheimer's disease: an update on emerging mechanisms

DJR Lane, S Ayton, AI Bush - Journal of Alzheimer's Disease, 2018 - content.iospress.com
Iron dyshomeostasis has been strongly linked to the pathogenesis of Alzheimers disease
(AD), as well as other major neurodegenerative diseases. Despite the growing societal …

Iron and Alzheimer's disease: from pathogenesis to therapeutic implications

JL Liu, YG Fan, ZS Yang, ZY Wang… - Frontiers in neuroscience, 2018 - frontiersin.org
… Abnormal iron metabolism generates hydroxyl radicals through the Fenton reaction, triggers
… There is an imbalance in iron homeostasis in Alzheimers disease (AD). Excessive iron

Iron neurochemistry in Alzheimer's disease and Parkinson's disease: targets for therapeutics

AA Belaidi, AI Bush - Journal of neurochemistry, 2016 - Wiley Online Library
… 0 s diseases. Finally, we discuss recent findings implicating iron as a diagnostic and
therapeutic target for Alzheimers and Parkinson’s diseases. Keywords: Alzheimer0s …

Iron, neuroinflammation, and Alzheimer's disease

WY Ong, AA Farooqui - Journal of Alzheimer's Disease, 2005 - content.iospress.com
… and interactions of iron and neuroinflammation in Alzheimers disease. It highlights … iron
accumulation, and iron-dependent oxidative damage. Elevation of iron in Alzheimers disease

Iron homeostasis disorder and Alzheimer's disease

Y Peng, X Chang, M Lang - International journal of molecular sciences, 2021 - mdpi.com
… cures for the disease. This paper … iron and AD from the aspects of iron absorption in intestinal
cells, storage and regulation of iron in cells and organs, especially for the regulation of iron

Iron and Alzheimer's disease: from pathology to imaging

D Tran, P DiGiacomo, DE Born… - Frontiers in Human …, 2022 - frontiersin.org
… evidence of pathological iron accumulation in the … iron accumulation and dysregulation in
AD, which may help in developing iron-based biomarkers or therapeutic targets for the disease

Oxidative stress and redox‐active iron in Alzheimer's disease

K Honda, G Casadesus, RB Petersen… - Annals of the new …, 2004 - Wiley Online Library
… stages of the disease, show elevated iron deposition. However, it is clear that the iron bound
to … , late role in the disease, with the RNA-associated iron found in the neuronal cytoplasm …

Treating Alzheimer's disease by targeting iron

S Nikseresht, AI Bush, S Ayton - British journal of pharmacology, 2019 - Wiley Online Library
… mechanism is called for, and trialling of new therapeutic approaches to slow disease … for
targeting brain iron in Alzheimer's disease. Although iron elevation in Alzheimer's disease was …

MRI for iron mapping in Alzheimer's disease

C Langkammer, S Ropele, L Pirpamer… - … diseases, 2014 - karger.com
… role of iron in Alzheimer's disease (AD). It is currently unclear as to whether iron accumulation
… Objective: We discuss currently available MR methods for quantitative iron mapping in the …

Copper and iron in Alzheimer's disease: a systematic review and its dietary implications

M Loef, H Walach - British Journal of Nutrition, 2012 - cambridge.org
… Copper and iron in Alzheimers disease: a systematic review and its dietary implications …
Abstract Fe and Cu could represent dietary risk factors for Alzheimers disease (AD), which has …