Adenosine triphosphate (ATP) and other nucleotides can be released in the central and
peripheral nervous systems and act as neurotransmitters/neuromodulators. They can
activate G-protein coupled receptors and ligand-gated ion channels, which are present
throughout the central nervous system (CNS). P2X2 is one of seven known ion channels
gated by ATP, and is characterized by having two transmembrane domains, a large
extracellular loop and intracellular N-and C-termini. Recently, work from several laboratories …