Isorhamnetin ameliorates inflammatory responses and articular cartilage damage in the rats of monosodium iodoacetate-induced osteoarthritis
SW Tsai, CC Lin, SC Lin, SP Wang… - Immunopharmacology …, 2019 - Taylor & Francis
SW Tsai, CC Lin, SC Lin, SP Wang, DH Yang
Immunopharmacology and immunotoxicology, 2019•Taylor & FrancisContext: Osteoarthritis (OA) is a degenerative joint disease with damage to the articular
cartilage. Active production of inflammatory cytokine/chemokine and matrix
metalloproteinases may be found during the progression of OA. Isorhamnetin had the effects
of anti-inflammatory, antioxidant, anti-ischemia, anti-atherosclerotic hepatoprotective and
anticancer activities. Objective: Our study was focused on the effects of isorhamnetin
treatment in OA. Materials and methods: We used monosodium iodoacetate (MIA)-induced …
cartilage. Active production of inflammatory cytokine/chemokine and matrix
metalloproteinases may be found during the progression of OA. Isorhamnetin had the effects
of anti-inflammatory, antioxidant, anti-ischemia, anti-atherosclerotic hepatoprotective and
anticancer activities. Objective: Our study was focused on the effects of isorhamnetin
treatment in OA. Materials and methods: We used monosodium iodoacetate (MIA)-induced …
Abstract
Context: Osteoarthritis (OA) is a degenerative joint disease with damage to the articular cartilage. Active production of inflammatory cytokine/chemokine and matrix metalloproteinases may be found during the progression of OA. Isorhamnetin had the effects of anti-inflammatory, antioxidant, anti-ischemia, anti-atherosclerotic hepatoprotective and anticancer activities.
Objective: Our study was focused on the effects of isorhamnetin treatment in OA.
Materials and methods: We used monosodium iodoacetate (MIA)-induced OA rats to evaluate the effects of isorhamnetin related anti-inflammatory process. The rats in all groups were sacrificed on four weeks post-MIA injection. The measurements of knee joint swelling, histological analysis, serum inflammatory biomarkers and western blot were evaluated.
Results: We found that isorhamnetin may reduce MIA-induced knee swelling by significantly reduction of articular cartilage damage.in rats. Suppression of pro-inflammatory cytokines production was found after isohamnetin treatment. Isorhamnetin inhibited the production of NO and PGE2, and the expression of iNOS and COX-2. The production of COMP, CTX-II and osteopontin (OPN) were also inhibited in MIA-induced OA rats.
Discussion and conclusions: Isorhamnetin may modulate the inflammatory progression of OA in MIA-induced OA rats. The prevention of cartilage damage was found in OA after adequate isorhamnetin treatment. Isorhamnetin may serve as a potential agent for the management of OA.
Taylor & Francis Online以上显示的是最相近的搜索结果。 查看全部搜索结果