KB-R7943, a Na+/Ca2+ exchange inhibitor, does not suppress ischemia/reperfusion arrhythmias nor digitalis arrhythmias in dogs
S Miyamoto, BM Zhu, K Kamiya… - The Japanese Journal …, 2002 - jstage.jst.go.jp
KB-R7943 (2-[2-[4-(4-nitrobenzyloxy) phenyl] ethyl] isothiourea methanesulfonate) has been
used as a pharmacological tool to block the Ca 2+ influx-mode of the Na+/Ca 2+ exchanger,
which is thought to contribute to ischemia/reperfusion and digitalis arrhythmias. We
examined effects of KB-R7943 on ischemia/reperfusion arrhythmias in beagle dogs
anesthetized with sodium pentobarbital. Lead II ECG and BP were measured. KB-R7943 or
the solvent (10% DMSO) was injected iv as a bolus, and 5 min later, the left anterior …
used as a pharmacological tool to block the Ca 2+ influx-mode of the Na+/Ca 2+ exchanger,
which is thought to contribute to ischemia/reperfusion and digitalis arrhythmias. We
examined effects of KB-R7943 on ischemia/reperfusion arrhythmias in beagle dogs
anesthetized with sodium pentobarbital. Lead II ECG and BP were measured. KB-R7943 or
the solvent (10% DMSO) was injected iv as a bolus, and 5 min later, the left anterior …
KB-R7943, a Na [+]/Ca [2+] Exchange Inhibitor, Does Not Suppress Ischemia/Reperfusion Arrhythmias nor Digitalis Arrhythmias in Dogs
M Shigeki, Z Bing-Mei, K Kazunori, N Yoshinobu… - Jpn. J. Pharmacol., 2002 - cir.nii.ac.jp
抄録 KB-R7943 (2-[2-[4-(4-nitrobenzyloxy) phenyl] ethyl] isothiourea methanesulfonate) has
been used as a pharmacological tool to block the Ca 2+ influx-mode of the Na+/Ca 2+
exchanger, which is thought to contribute to ischemia/reperfusion and digitalis arrhythmias.
We examined effects of KB-R7943 on ischemia/reperfusion arrhythmias in beagle dogs
anesthetized with sodium pentobarbital. Lead II ECG and BP were measured. KB-R7943 or
the solvent (10% DMSO) was injected iv as a bolus, and 5 min later, the left anterior …
been used as a pharmacological tool to block the Ca 2+ influx-mode of the Na+/Ca 2+
exchanger, which is thought to contribute to ischemia/reperfusion and digitalis arrhythmias.
We examined effects of KB-R7943 on ischemia/reperfusion arrhythmias in beagle dogs
anesthetized with sodium pentobarbital. Lead II ECG and BP were measured. KB-R7943 or
the solvent (10% DMSO) was injected iv as a bolus, and 5 min later, the left anterior …
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