Objective—Mutations in Krüppel like factor-11 (KLF11), a gene also known as maturity-onset
diabetes mellitus of the young type 7, contribute to the development of diabetes mellitus.
KLF11 has anti-inflammatory effects in endothelial cells and beneficial effects on stroke.
However, the function of KLF11 in the cardiovascular system is not fully unraveled. In this
study, we investigated the role of KLF11 in vascular smooth muscle cell biology and arterial
thrombosis. Approach and Results—Using a ferric chloride–induced thrombosis model, we …

Introduction: Emerging studies have indicated the important link between vessel wall and
thrombosis, while the precise mechanisms mediating the injured vessel wall-induced arterial
thrombosis remain largely unexplored. Krüpple-like Factor 11 (KLF11) regulates lipid and
glucose metabolism, inhibits endothelial inflammation, and has beneficial effect on stroke.
However, the role of KLF11 in thrombotic homeostasis and arterial thrombosis remains
unknown. Hypothesis: We hypothesize that KLF11 protects against arterial thrombosis via …