KSHV miRNAs decrease expression of lytic genes in latently infected PEL and endothelial cells by targeting host transcription factors
Kaposi's sarcoma-associated herpesvirus (KSHV) microRNAs are encoded in the latency-
associated region. Knockdown of KSHV miR-K12-3 and miR-K12-11 increased expression
of lytic genes in BC-3 cells, and increased virus production from latently infected BCBL-1
cells. Furthermore, iSLK cells infected with miR-K12-3 and miR-K12-11 deletion mutant
viruses displayed increased spontaneous reactivation and were more sensitive to inducers
of reactivation than cells infected with wild type KSHV. Predicted binding sites for miR-K12-3 …
associated region. Knockdown of KSHV miR-K12-3 and miR-K12-11 increased expression
of lytic genes in BC-3 cells, and increased virus production from latently infected BCBL-1
cells. Furthermore, iSLK cells infected with miR-K12-3 and miR-K12-11 deletion mutant
viruses displayed increased spontaneous reactivation and were more sensitive to inducers
of reactivation than cells infected with wild type KSHV. Predicted binding sites for miR-K12-3 …
[引用][C] KSHV miRNAs decrease expression of lytic genes in latently infected PEL and endothelial cells by targeting host transcription factors. Viruses. 2014; 6: 4005 …
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