Kinetic resolution of racemic 1-(benzofuran-2-yl) ethanols rac-1a–d was performed by lipase-
catalyzed enantiomer selective acylation (E≫ 100) yielding (1R)-1-acetoxy-1-(benzofuran-2-
yl) ethanes (R)-2a–d and (1S)-1-(benzofuran-2-yl) ethanols (S)-1a–d in highly enantiopure
form. The degree of enantiomer selectivity for enzymatic alcoholysis/hydrolysis processes
starting from racemic 1-acetoxy-1-(benzofuran-2-yl) ethane rac-2 was also tested under
various conditions including supercritical CO2 medium. Racemization-free lipase-catalyzed …