Kinetic resolution of trans-2-acetoxycycloalkan-1-ols by lipase-catalysed enantiomerically selective acylation
V Bódai, O Orovecz, G Szakács, L Novák… - Tetrahedron: Asymmetry, 2003 - Elsevier
Kinetic resolution of a series of racemic trans-cycloalkane-1, 2-diol monoacetates rac-2a–d
was performed by enantiomerically selective transesterification with vinyl acetate catalysed
by commercial and our own-prepared fungal lipases to yield diacetates (R, R)-3a–d and
monoacetates (S, S)-2a–d in high enantiomeric purity. The monoacetates (R, R)-2a–d were
also prepared from the racemic diacetates rac-3a–d by lipase-catalysed hydrolysis.
was performed by enantiomerically selective transesterification with vinyl acetate catalysed
by commercial and our own-prepared fungal lipases to yield diacetates (R, R)-3a–d and
monoacetates (S, S)-2a–d in high enantiomeric purity. The monoacetates (R, R)-2a–d were
also prepared from the racemic diacetates rac-3a–d by lipase-catalysed hydrolysis.