… suppress Nanog expression in mouse ESCs [8]. To examine the effect of p53 knockdown on
Nanog expression … MMC, an activator of the DNA damage p53/apoptosis pathway [19]. We …

… This result demonstrated that Oct4 or Nanog knockdown suppressed mESCs proliferation, …
with p53-upregulated modulator of apoptosis (PUMA) [22]. Igf-bp3 inhibits cell growth and …

… that SIRT1 blocks nuclear translocation of cytoplasmic p53 in … apoptosis in mouse
embryonic stem (mES) cells. ROS … suppression of Nanog was blocked by knockdown of p53 in …

… Furthermore, p53 knockdown resulted in a significant downregulation in Nanog expression
at 24 and 48 h post-transfection. p53 knockdown also caused a reduction in Oct4 expression …

… -mediated knockdown of p53 delays differentiation, whereas … of NANOG and spontaneous
differentiation into other cell … G1 elongation, blocks deactivation of p53 by targeting the …

… To examine the effect of 264 p53 knockdown on Nanog expression after exposure of
mouse ESCs … differentiation of mouse embryonic stem cells by suppressing Nanog …

… The main finding of this study is that knockdown of Trp53 and Pten independently resulted
… p53 induces differentiation of mouse embryonic stem cells by suppressing Nanog expression…

… We isolated T lymphocytes from Nanog–GFP reporter mice that were either p53 wild-type or
… -null MEF by DNA microarrays, and between control HDF and p53 knockdown HDF. In MEF, …

… of p53 as a critical mediator of human embryonic stem cells … , we irradiated the H1 human
embryonic stem cell line with UV. … h, the cells began to die; after 12 h, 67% of the irradiated cell …

… is considered a master transcriptional factor of embryonic stem cells (ESCs). … that p53-knockdown
significantly abrogated resveratrol-induced suppression of Nanog expression in GSCs. …