… However, the minimal defining features of RISC include the presence of an Argonaute …
The best-characterized pathway, and the one that is predominantly used for gene knockdown …

… system (gDNA/NgAgo) was used as a genetic tool to knock out a specific gene fabp11a,
eventually causing eye developmental defects in zebrafish [93]. It was also reported that the …

… Argonaute proteins are the central effectors of RNA-guided … Eukaryotic Argonautes are
subdivided into two clades: AGOs … It is currently unclear when and how Argonaute-based RNA …

… Eukaryotic Argonaute proteins mediate RNA-guided RNA interference, … Argonaute homologs
mediate DNA-guided DNA interference, and play a role in host defense. Argonaute of the …

… We find that knocking out AGO1, AGO2 and AGO3 together are necessary to achieve full …
levels of mRNA in wild-type versus knock out cells, including the strongest cluster within the …

… elegans Argonautes, knocking out all 27 worm Argonaute genes. They describe the function
as well as the small RNA partners for a number of previously uncharacterized family members …

… Argonaute proteins mediate gene regulation by small RNAs … Argonaute proteins, small
RNAs, and their roles in eukaryotic biology. Here, we review current understanding of Argonaute …

… in which an Argonaute gene was knocked out is more likely than the relationship with a
particular gene. In general, flies with neuronal knockdown of the Argonaute genes were sensitive …

… binding by Argonaute comes from studies of the Argonaute protein from the bacteria Thermus
thermophilus. Unlike its eukaryotic cousins, the Thermus thermophilus Argonaute uses a …

… Ago2 is a member of the evolutionarily conserved Argonaute … pathway-defective mosquitoes
by knocking out Ago2 in Ae. … aegypti siRNA pathway, we used CRISPR/Cas9 to knock out …