Many developmental genes are controlled by shadow enhancers—pairs of enhancers that
drive overlapping expression patterns. We hypothesized that compensatory evolution can
maintain the total expression of a gene, while individual shadow enhancers diverge
between species. To test this hypothesis, we analyzed expression driven by orthologous
pairs of shadow enhancers from Drosophila melanogaster, Drosophila yakuba, and
Drosophila pseudoobscura that control expression of Krüppel, a transcription factor that …

(Cell Reports 12, 1740–1747; Published September 22, 2015) In the originally published
version of this manuscript, there was an error in Figure S1C. A bug in our code caused the p
values reported in Figure S1C to be the probability (binding sites> x) instead of probability
(binding sites R x), as reported in the figure legend. We have corrected the code and the
figure. This correction does not change any of the conclusions of the paper. The figure has
since been corrected online.