Krüppel-Like Factor 4 (Klf4) Is a Stat3-Smad2 Regulator in ATII Cells Determining ATII Cell Fate During Lung Development and Hyperoxia-Induced Lung Injury
J Mohr, M Koch, S Danopoulos, L Ebert… - C28. PATHWAYS OF …, 2019 - atsjournals.org
RATIONALE: Premature infants exposed to mechanical ventilation (MV) and/or increased
O2 often develop bronchopulmonary dysplasia (BPD), a neonatal chronic lung disease,
characterized by a reduced alveolarization. We previously linked reduced Krüppel-like factor
4 (Klf4), a transcription factor regulating cell pluripotency and survival, to lung growth arrest.
Since type II alveolar epithelial cells (ATII cells) are alveolar progenitor cells, we studied the
impact of hyperoxia on Klf4 in newborn lungs and ATII homeostasis; and the functional role …
O2 often develop bronchopulmonary dysplasia (BPD), a neonatal chronic lung disease,
characterized by a reduced alveolarization. We previously linked reduced Krüppel-like factor
4 (Klf4), a transcription factor regulating cell pluripotency and survival, to lung growth arrest.
Since type II alveolar epithelial cells (ATII cells) are alveolar progenitor cells, we studied the
impact of hyperoxia on Klf4 in newborn lungs and ATII homeostasis; and the functional role …