Labrenzbactin from a coral-associated bacterium Labrenzia sp.
The Journal of Antibiotics, 2019•nature.com
A new catecholate-containing siderophore, labrenzbactin (1), was isolated from the
fermentation broth of a coral-associated bacterium Labrenzia sp. The structure and absolute
configuration of 1 was determined by spectroscopic methods and Marfey's analysis. Overall,
1 showed antimicrobial activity against Ralstonia solanacearum SUPP1541 and
Micrococcus luteus ATCC9341 with MIC values of 25 and 50 µg ml− 1, respectively, and
cytotoxicity against P388 murine leukemia cells with an IC50 of 13 µM.
fermentation broth of a coral-associated bacterium Labrenzia sp. The structure and absolute
configuration of 1 was determined by spectroscopic methods and Marfey's analysis. Overall,
1 showed antimicrobial activity against Ralstonia solanacearum SUPP1541 and
Micrococcus luteus ATCC9341 with MIC values of 25 and 50 µg ml− 1, respectively, and
cytotoxicity against P388 murine leukemia cells with an IC50 of 13 µM.
Abstract
A new catecholate-containing siderophore, labrenzbactin (1), was isolated from the fermentation broth of a coral-associated bacterium Labrenzia sp. The structure and absolute configuration of 1 was determined by spectroscopic methods and Marfey’s analysis. Overall, 1 showed antimicrobial activity against Ralstonia solanacearum SUPP1541 and Micrococcus luteus ATCC9341 with MIC values of 25 and 50 µg ml−1, respectively, and cytotoxicity against P388 murine leukemia cells with an IC50 of 13 µM.
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