Lack of vitamin D receptor causes stress-induced premature senescence in vascular smooth muscle cells through enhanced local angiotensin-II signals
Objectives The inhibition of the renal renin-angiotensin system by the active form of vitamin
D contributes to the cardiovascular health benefits of a normal vitamin D status. Local
production of angiotensin-II in the vascular wall is a potent mediator of oxidative stress,
prompting premature senescence. Herein, our objective was to examine the impact of
defective vitamin D signalling on local angiotensin-II levels and arterial health. Methods
Primary cultures of aortic vascular smooth muscle cells (VSMC) from wild-type and vitamin D …
D contributes to the cardiovascular health benefits of a normal vitamin D status. Local
production of angiotensin-II in the vascular wall is a potent mediator of oxidative stress,
prompting premature senescence. Herein, our objective was to examine the impact of
defective vitamin D signalling on local angiotensin-II levels and arterial health. Methods
Primary cultures of aortic vascular smooth muscle cells (VSMC) from wild-type and vitamin D …
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