Large-scale GWAS reveals genetic architecture of brain white matter microstructure and genetic overlap with cognitive and mental health traits (n = 17,706)
Individual variations of white matter (WM) tracts are known to be associated with various
cognitive and neuropsychiatric traits. Diffusion tensor imaging (DTI) and genome-wide
single-nucleotide polymorphism (SNP) data from 17,706 UK Biobank participants offer the
opportunity to identify novel genetic variants of WM tracts and explore the genetic overlap
with other brain-related complex traits. We analyzed the genetic architecture of 110 tract-
based DTI parameters, carried out genome-wide association studies (GWAS), and …
cognitive and neuropsychiatric traits. Diffusion tensor imaging (DTI) and genome-wide
single-nucleotide polymorphism (SNP) data from 17,706 UK Biobank participants offer the
opportunity to identify novel genetic variants of WM tracts and explore the genetic overlap
with other brain-related complex traits. We analyzed the genetic architecture of 110 tract-
based DTI parameters, carried out genome-wide association studies (GWAS), and …
Large-scale GWAS reveals genetic architecture of brain white matter microstructure and genetic overlap with cognitive and mental health traits (n= 17,706)
Background Individual variations of white matter (WM) tracts are known to be associated
with various cognitive and neuropsychiatric traits. Diffusion tensor imaging (DTI) and
genome-wide single-nucleotide polymorphism (SNP) data from 17,706 UK Biobank
participants offer opportunity to identify novel genetic variants of WM tracts and explore the
genetic overlap with other brain-related complex traits. Method We analyzed the genetic
architecture of 110 tract-based DTI parameters, carried out genome-wide association …
with various cognitive and neuropsychiatric traits. Diffusion tensor imaging (DTI) and
genome-wide single-nucleotide polymorphism (SNP) data from 17,706 UK Biobank
participants offer opportunity to identify novel genetic variants of WM tracts and explore the
genetic overlap with other brain-related complex traits. Method We analyzed the genetic
architecture of 110 tract-based DTI parameters, carried out genome-wide association …
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