Layer-by-layer immobilization of amphoteric carboxymethyl chitosan onto biocompatible silk fibroin nanofibrous mats

H Tu, G Wu, Y Yi, M Huang, R Liu, X Shi, H Deng - Carbohydrate polymers, 2019 - Elsevier
H Tu, G Wu, Y Yi, M Huang, R Liu, X Shi, H Deng
Carbohydrate polymers, 2019Elsevier
Novel antimicrobials with well biocompatibility are urgently needed for human public health
protecting. Here, the silk fibroin (SF) nanofibrous mats coated with carboxymethyl chitosan
(CMC), both extracted from natural polymers, were fabricated by combining electrospinning
and electrostatic layer-by-layer (LBL) self-assembly techniques. The amphoteric CMC could
be easily adsorbed on the surface of SF nanofibers due to the electrostatic interaction, which
were a highly efficient and “green” route for the surface modification of SF mats. The mats …
Abstract
Novel antimicrobials with well biocompatibility are urgently needed for human public health protecting. Here, the silk fibroin (SF) nanofibrous mats coated with carboxymethyl chitosan (CMC), both extracted from natural polymers, were fabricated by combining electrospinning and electrostatic layer-by-layer (LBL) self-assembly techniques. The amphoteric CMC could be easily adsorbed on the surface of SF nanofibers due to the electrostatic interaction, which were a highly efficient and “green” route for the surface modification of SF mats. The mats after LBL procedure exhibited better hydrophilicity and stronger mechanical properties. The experimental results demonstrated that the LBL modified mats not only kept well biocompatibility but also obtained extremely enhanced antibacterial activity. More importantly, the mats displayed better bacterial inhibition with the increased CMC layers. LBL10 and LBL10.5 owned the antibacterial activity of more than 67% at the bacterial concentrations of 106 cfu ml−1 after 24 h cultivation, which implied that these novel natural polymer-based materials could be utilized as wound dressings for clinical skin and tissue regeneration, especially for infected wounds.
Elsevier
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