Lectin-gated, mesoporous, photofunctionalized glyconanoparticles for glutathione-responsive drug delivery
J Zhou, N Hao, T De Zoyza, M Yan… - Chemical …, 2015 - pubs.rsc.org
J Zhou, N Hao, T De Zoyza, M Yan, O Ramström
Chemical Communications, 2015•pubs.rsc.orgA stimuli-responsive drug delivery system based on fluorescent, lectin-gated, mesoporous
glyconanoparticles has been developed and evaluated in normal-and cancer lung epithelial
cells. The gating process proved efficient, exhibiting good sealing properties in the absence
of the glutathione redox trigger, avoiding premature release in normal cells. In the presence
of higher levels of glutathione in cancer cells, the lectin gate was rapidly opened and the
anticancer drug released.
glyconanoparticles has been developed and evaluated in normal-and cancer lung epithelial
cells. The gating process proved efficient, exhibiting good sealing properties in the absence
of the glutathione redox trigger, avoiding premature release in normal cells. In the presence
of higher levels of glutathione in cancer cells, the lectin gate was rapidly opened and the
anticancer drug released.
A stimuli-responsive drug delivery system based on fluorescent, lectin-gated, mesoporous glyconanoparticles has been developed and evaluated in normal- and cancer lung epithelial cells. The gating process proved efficient, exhibiting good sealing properties in the absence of the glutathione redox trigger, avoiding premature release in normal cells. In the presence of higher levels of glutathione in cancer cells, the lectin gate was rapidly opened and the anticancer drug released.
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