Ligand specificity of odorant receptors

K Khafizov, C Anselmi, A Menini, P Carloni - Journal of molecular modeling, 2007 - Springer
… nine amino-acid residues involved in ligand binding. Our modeling provides a … the odorant
receptors considered and helps to identify other amino acids that could be important for ligand

The molecular basis for ligand specificity in a mouse olfactory receptor: a network of functionally important residues

T Abaffy, A Malhotra, CW Luetje - Journal of Biological Chemistry, 2007 - ASBMB
… Here we report the structural basis for ligand specificity of an OR (MOR42-3) by combining
ligand docking studies. MOR42-3 is closely related to MOR42-1, and both of these receptors

Searching for the ligands of odorant receptors

B Malnic - Molecular neurobiology, 2007 - Springer
… the odorant specificities of individual odorant receptors. These … family and by the poor
functional expression of these receptors … used to investigate odorant receptorligand interactions. …

Structural basis for a broad but selective ligand spectrum of a mouse olfactory receptor: mapping the odorant-binding site

S Katada, T Hirokawa, Y Oka, M Suwa… - Journal of …, 2005 - Soc Neuroscience
… examined the ligand specificity of mOR-EG. We found that this receptor recognizes 22 odorants
that … We then attempted to elucidate the odorant-binding environment in mOR-EG and to …

Molecular determinants of ligand selectivity in a vertebrate odorant receptor

P Luu, F Acher, HO Bertrand, J Fan… - Journal of …, 2004 - Soc Neuroscience
… importance of specific binding pocket sites as determinants of ligand selectivity. From this
analysis, we propose a general model of ligand recognition for amino acid odorant receptors. …

Olfactory receptors: molecular basis for recognition and discrimination of odors

H Breer - Analytical and bioanalytical chemistry, 2003 - Springer
Ligand specificity of olfactory receptors … Instead of dedicating an individual odor receptor
to a specific odor, the olfactory system uses an "alphabet" of receptors to create a specific odor

Odorant receptors and odorant-binding proteins as insect pest control targets: a comparative analysis

H Venthur, JJ Zhou - Frontiers in physiology, 2018 - frontiersin.org
… For the case of OBPs, the ligand specificity and mechanisms … used for the measurement of
ligand affinity. For instance, it … could enhance specificity and sensitivity of odorant reception. …

Functional identification and reconstitution of an odorant receptor in single olfactory neurons

K Touhara, S Sengoku, K Inaki… - Proceedings of the …, 1999 - National Acad Sciences
… The ligandreceptor interaction, however, has not been clearly … of olfactory receptor(s)
for specific odorant(s) from single … expression and ligand screening of odorant receptor was …

[HTML][HTML] Identification of ligands for olfactory receptors by functional expression of a receptor library

D Krautwurst, KW Yau, RR Reed - Cell, 1998 - cell.com
… neuron should depend on the ligand specificity of the one or few receptor proteins it …
for the study of ligand specificity and structure–function relationships for olfactory receptors. …

Ligand specificity and evolution of mammalian musk odor receptors: effect of single receptor deletion on odor detection

N Sato-Akuhara, N Horio, A Kato-Namba… - Journal of …, 2016 - Soc Neuroscience
odorants and related compounds. We found that each species has one or two functional musk
ORs that exhibit specific ligand … The ligand specificity of OR5AN1 reflects the perception of …