Lipid‐based bio‐nanohybrids for functional stabilisation of influenza vaccines
B Wicklein, MÁ Martín del Burgo… - European Journal of …, 2012 - Wiley Online Library
Lipid‐based bio‐nanohybrids were evaluated as carriers of viral particles in the
development of thermally stable and efficacious vaccines against influenza A. Herein, the
surfaces of the microfibrous clay sepiolite and the Mg/Al‐type layered double hydroxide
were modified with a bilayer lipid membrane on which influenza A virions were immobilised.
These vaccines were highly immunogenic in mice and stability studies revealed that thermal
and lyophilisation resistance were significantly enhanced when compared with a standard …
development of thermally stable and efficacious vaccines against influenza A. Herein, the
surfaces of the microfibrous clay sepiolite and the Mg/Al‐type layered double hydroxide
were modified with a bilayer lipid membrane on which influenza A virions were immobilised.
These vaccines were highly immunogenic in mice and stability studies revealed that thermal
and lyophilisation resistance were significantly enhanced when compared with a standard …
Lipid-based bio-nanohybrids for functional stabilisation of influenza vaccines
M Martín del Burgo, M Darder, CE Llavata… - Departamento de …, 2012 - digital.csic.es
Lipid-based bio-nanohybrids were evaluated as carriers of viral particles in the development
of thermally stable and efficacious vaccines against influenza A. Herein, the surfaces of the
microfibrous clay sepiolite and the Mg/Al-type layered double hydroxide were modified with
a bilayer lipid membrane on which influenza A virions were immobilised. These vaccines
were highly immunogenic in mice and stability studies revealed that thermal and
lyophilisation resistance were significantly enhanced when compared with a standard …
of thermally stable and efficacious vaccines against influenza A. Herein, the surfaces of the
microfibrous clay sepiolite and the Mg/Al-type layered double hydroxide were modified with
a bilayer lipid membrane on which influenza A virions were immobilised. These vaccines
were highly immunogenic in mice and stability studies revealed that thermal and
lyophilisation resistance were significantly enhanced when compared with a standard …
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