Lipid nanoparticles enhance the efficacy of mRNA and protein subunit vaccines by inducing robust T follicular helper cell and humoral responses
Adjuvants are critical for improving the quality and magnitude of adaptive immune
responses to vaccination. Lipid nanoparticle (LNP)-encapsulated nucleoside-modified
mRNA vaccines have shown great efficacy against severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), but the mechanism of action of this vaccine platform is not well-
characterized. Using influenza virus and SARS-CoV-2 mRNA and protein subunit vaccines,
we demonstrated that our LNP formulation has intrinsic adjuvant activity that promotes …
responses to vaccination. Lipid nanoparticle (LNP)-encapsulated nucleoside-modified
mRNA vaccines have shown great efficacy against severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), but the mechanism of action of this vaccine platform is not well-
characterized. Using influenza virus and SARS-CoV-2 mRNA and protein subunit vaccines,
we demonstrated that our LNP formulation has intrinsic adjuvant activity that promotes …
Lipid nanoparticles enhance the efficacy of mRNA and protein subunit vaccines by inducing robust T follicular helper cell and humoral responses
(Immunity 54, 2877–2892. e1–e7, December 14, 2021) Due to an oversight, two authors
were omitted from the author list. The author list, the author contribution section, and the
acknowledgments have been updated and corrected online and in print. The authors
apologize for the error.
were omitted from the author list. The author list, the author contribution section, and the
acknowledgments have been updated and corrected online and in print. The authors
apologize for the error.
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