Lipid-polyethylene glycol based nano-ocular formulation of ketoconazole
S Kakkar, SM Karuppayil, JS Raut, F Giansanti… - International journal of …, 2015 - Elsevier
Ophthalmic mycoses including corneal keratitis or endophthalmitis affects 6-million
persons/year and can cause blindness. Its management requires antifungals to penetrate
the ocular tissue. Oral use of Ketoconazole (KTZ), the first broad-spectrum antifungal to be
marketed, is now restricted to life-threatening infections due to severe adverse effects and
drug-interactions. Local use of KTZ loaded nanocarrier system can address its toxicity, poor
solubility, photodegradation, permeation and bioavailability issues. Solid lipid nanoparticles …
persons/year and can cause blindness. Its management requires antifungals to penetrate
the ocular tissue. Oral use of Ketoconazole (KTZ), the first broad-spectrum antifungal to be
marketed, is now restricted to life-threatening infections due to severe adverse effects and
drug-interactions. Local use of KTZ loaded nanocarrier system can address its toxicity, poor
solubility, photodegradation, permeation and bioavailability issues. Solid lipid nanoparticles …
Lipid-polyethylene glycol based nano-ocular formulation of ketoconazole.
SK Shilpa Kakkar, SM Karuppayil, JS Raut, F Giansanti… - 2015 - cabidigitallibrary.org
Ophthalmic mycoses including corneal keratitis or endophthalmitis affects 6-million
persons/year and can cause blindness. Its management requires antifungals to penetrate
the ocular tissue. Oral use of Ketoconazole (KTZ), the first broad-spectrum antifungal to be
marketed, is now restricted to life-threatening infections due to severe adverse effects and
drug-interactions. Local use of KTZ loaded nanocarrier system can address its toxicity, poor
solubility, photodegradation, permeation and bioavailability issues. Solid lipid nanoparticles …
persons/year and can cause blindness. Its management requires antifungals to penetrate
the ocular tissue. Oral use of Ketoconazole (KTZ), the first broad-spectrum antifungal to be
marketed, is now restricted to life-threatening infections due to severe adverse effects and
drug-interactions. Local use of KTZ loaded nanocarrier system can address its toxicity, poor
solubility, photodegradation, permeation and bioavailability issues. Solid lipid nanoparticles …
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