Lipiodol solution of a lipophilic agent, 188Re-TDD, for the treatment of liver cancer
Radiolabeled lipiodol has been used for targeting liver cancer. We developed a lipiodol
solution of 188Re-TDD (2, 2, 9, 9-tetramethyl-4, 7-diaza-1, 10-decanedithiol) and
investigated its feasibility for the treatment of liver cancer. The lipiodol solution of 188Re-
TDD was well-retained in the lipiodol phase in vitro. After injection through the tail veins of
mice, high lung-uptake was investigated which is evidence of embolizing activity. We also
found high accumulation in hepatoma after injection through the hepatic arteries of …
solution of 188Re-TDD (2, 2, 9, 9-tetramethyl-4, 7-diaza-1, 10-decanedithiol) and
investigated its feasibility for the treatment of liver cancer. The lipiodol solution of 188Re-
TDD was well-retained in the lipiodol phase in vitro. After injection through the tail veins of
mice, high lung-uptake was investigated which is evidence of embolizing activity. We also
found high accumulation in hepatoma after injection through the hepatic arteries of …
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