[HTML][HTML] Liver X receptor regulates Th17 and RORγt+ Treg cells by distinct mechanisms
SM Parigi, S Das, A Frede, RF Cardoso, KP Tripathi… - Mucosal …, 2021 - Elsevier
The gastrointestinal microenvironment, dominated by dietary compounds and the
commensal bacteria, is a major driver of intestinal CD4+ T helper (Th) cell differentiation.
Dietary compounds can be sensed by nuclear receptors (NRs) that consequently exert
pleiotropic effects including immune modulation. Here, we found that under homeostatic
conditions the NR Liver X receptor (LXR), a sensor of cholesterol metabolites, regulates
RORγt+ CD4 T cells in the intestine draining mesenteric lymph node (MLN). While LXR …
commensal bacteria, is a major driver of intestinal CD4+ T helper (Th) cell differentiation.
Dietary compounds can be sensed by nuclear receptors (NRs) that consequently exert
pleiotropic effects including immune modulation. Here, we found that under homeostatic
conditions the NR Liver X receptor (LXR), a sensor of cholesterol metabolites, regulates
RORγt+ CD4 T cells in the intestine draining mesenteric lymph node (MLN). While LXR …
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